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Software System for Analyzing Three-Dimensional Image Data of a Target Region
- Application in Early Prediction of Tumour Recurrence after Stereotactic Ablative Radiotherapy for Lung Cancer
BackgroundStereotactic ablative therapy (SABR) is a standard treatment for individuals with early stage non-small lung cancer who are medically inoperable or refuse surgery. This highly conformal, high-dose radiation therapy alters the radiographic appearance of the lung during follow-up computer tomography (CT) imaging assessment in ways that are not...
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RanBPM shRNA HeLa cell line as a research tool
Summary: Researchers at Western University have developed stable RanBPM shRNA HeLa cell line as a research tool. Background: Ran-Binding Protein M (RanBPM) has been previously shown to inhibit c-Raf expression, however how this was achieved remains unclear. c-Raf is the central component of the extracellular signal-regulated kinase (ERK) pathway which...
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DNA methylation assay for diagnosis and screening of prostate cancer
BackgroundProstatic adenocarcinoma is the most commonly diagnosed non-cutaneous cancer for men in the United States. The incidence is likely to continue to increase as people survive longer and more middle-aged men undergo routine screening for the disease. Men diagnosed with early stage small volume disease have the best outcome following curative...
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Peptides targeting EGFL7, a critical player in angiogenesis
Background:Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial cell...
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Ghrelin Analogues as Molecular Imaging Probes
Background: Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues. Expression of the GHSR has been reported in various types of tumors, including breast carcinomas, prostate cancer cell lines, ovarian tumors,...
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