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Novel Blood Metabolomics Profiling for Concussion Diagnosis
A metabolomics based blood test has been developed that can determine evenmild concussions with up to 95% accuracy.BackgroundTraumatic brain injury (TBI) is a major public health concern of epidemic proportions, with an annual incidence of 1.6 to 3.2 million in the United States. Mild TBI, of which concussion is a subset, is the most common representing...
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Determining Urinary Calculi Composition
BackgroundAccurate determination of urinary stone composition has significant bearing on understanding pathophysiology, choosing treatment modalities and preventing recurrence. Several modalities to determine stone composition exist (e.g., chemical analysis, X-ray diffraction and infrared spectroscopy); however, all of these methods require direct access...
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Diagnosis of Bacterial Vaginosis (BV)
BackgroundBacterial vaginosis (BV) is the most common vaginal condition, affecting an estimated 30% of women at any given time. While many women remain asymptomatic, when signs and symptoms do arise they include an elevated vaginal pH>4.5, discharge, and malodour due to amines. BV is also associated with a number of co-morbidities, including increased...
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Multidimensional Pain Measurement Application Tool
Multidimensional Pain Measurement Application ToolSummaryRobust and Innovative Aid in the Clinical Management of people with chronic pain by applying new assessment to the way pain is measuredBackgroundPain and distress are difficult to quantify common to almost all illnesses, and according to the National Institute of Health (NIH), affects more individuals...
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DNA methylation assay for diagnosis and screening of prostate cancer
BackgroundProstatic adenocarcinoma is the most commonly diagnosed non-cutaneous cancer for men in the United States. The incidence is likely to continue to increase as people survive longer and more middle-aged men undergo routine screening for the disease. Men diagnosed with early stage small volume disease have the best outcome following curative...
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Ghrelin Analogues as Molecular Imaging Probes
Background: Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues. Expression of the GHSR has been reported in various types of tumors, including breast carcinomas, prostate cancer cell lines, ovarian tumors,...
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