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Highly Specific Approach for Detection of Salivary Biomarkers of Zika Fever
Background Clinical symptoms of zika fever are non-specific. In pregnant women, ZIKV (zika virus) could cause fetal microcephaly. In addition, ZIKV not only appears to severely harm unborn children but is also hurting the economies of many South and Central American countries. For instance, The World Bank calculated that the global economic cost of...
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Treatment of central nervous system injuries through targeted reduction of neuroinflammation
BackgroundTraumatic injuries to the brain and spinal cord are a leading cause of death among young people. Patients who are fortunate to survive the initial injury often deal with lifelong neurological impairment. With incident rates on the rise, TBI and SCI are poised to become a major contributor to the global epidemiological and economic burden...
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Novel Blood Metabolomics Profiling for Concussion Diagnosis
A metabolomics based blood test has been developed that can determine evenmild concussions with up to 95% accuracy.BackgroundTraumatic brain injury (TBI) is a major public health concern of epidemic proportions, with an annual incidence of 1.6 to 3.2 million in the United States. Mild TBI, of which concussion is a subset, is the most common representing...
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Biopsy Needle System to Prevent P. acnes Contamination
BackgroundInfections are a potentially devastating complication of any surgery. Amongst the most devastating are post-surgical joint infections caused by Propionibacterium acnes (P. acnes), now considered the major microbial cause of surgical implant failures. Without early diagnosis and intervention, these infections result in joint tissue necrosis...
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Dual Purpose Upper and Lower Limb Rehabilitation Robot
BackgroundThere are 800,000 new cases of stroke in the United States and Canada each year. In cases of stroke, it is common for the upper and lower limbs to become weakened or paralyzed. Robotic rehabilitation systems have been developed to assist in the delivery of movement therapy to both the upper or lower extremities to maximize return of function...
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Selective Brain Cooling Technology
BackgroundBrain cooling (hypothermia) has been shown to prevent brain injury (neuroprotection) from stroke, brain trauma and cardiac arrest in both animal models and patient studies. Currently, the main hurdles in the clinical application of hypothermia are: 1) most brain cooling methods also cool down the rest of the body with its associated complications...
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Software System for Analyzing Three-Dimensional Image Data of a Target Region
- Application in Early Prediction of Tumour Recurrence after Stereotactic Ablative Radiotherapy for Lung Cancer
BackgroundStereotactic ablative therapy (SABR) is a standard treatment for individuals with early stage non-small lung cancer who are medically inoperable or refuse surgery. This highly conformal, high-dose radiation therapy alters the radiographic appearance of the lung during follow-up computer tomography (CT) imaging assessment in ways that are not...
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Novel Mechanism to Control Pathogenic Potential of Staphylococcus aureus
Summary Researchers at Western University have identified a mutations in S. aureus purine biosynthesis pathway that contribute to its virulence. The current invention opens up alternate treatment and target mechanisms for hard to treat S. aureus and MRSA. Background In humans, Staphylococcus aureus may exist as a commensal bacterium or as a pathogen....
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A yeast model for ALS and Distal Myopathy-2 Therapeutics
Title: A yeast model for ALS and Distal Myopathy-2 TherapeuticsSummary: A yeast model for high throughput drug and small molecule screening for ALS and Distal Myopathy-2Background: Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease caused by loss of the upper motor neurons, i.e. neurons that extend from the cortex to the...
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High Affinity RHAMM/HMMR Binding
Peptides for Imaging and Therapeutic Applications
BackgroundHyaluronan (HA) is a simple extracellular matrix polysaccharide that a wealth of experimental approaches has demonstrated actively regulates inflammation in tissue repair, fibrogenic disease processes and cancer progression. In general, large HA polymers, which are mainly present in homeostatic tissues, are immunologically quiescent and contribute...
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