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High Affinity RHAMM/HMMR Binding
Peptides for Imaging and Therapeutic Applications
BackgroundHyaluronan (HA) is a simple extracellular matrix polysaccharide that a wealth of experimental approaches has demonstrated actively regulates inflammation in tissue repair, fibrogenic disease processes and cancer progression. In general, large HA polymers, which are mainly present in homeostatic tissues, are immunologically quiescent and contribute...
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Selective Brain Cooling Technology
BackgroundBrain cooling (hypothermia) has been shown to prevent brain injury (neuroprotection) from stroke, brain trauma and cardiac arrest in both animal models and patient studies. Currently, the main hurdles in the clinical application of hypothermia are: 1) most brain cooling methods also cool down the rest of the body with its associated complications...
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The Desired Sensation Level Multi-stage [i/o] Algorithm
The Desired Sensation Level: DSL [i/o] algorithm was released to manufacturers in the late 1990s in the form of a dynamic loadable/linked library (DLL). We appreciate your support and want you to know that the money that we have received from manufacturers in the form of license fees for the DLL is put back into research, development and technical support...
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miR-195 Antagomir Treatment of Sepsis
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules encoded by eukaryotic nuclear DNA, on average 22 nucleotides long, that function in transcriptional and post-transcriptional regulation of gene expression via base-pairing with complementary sequences within mRNA molecules, usually resulting in gene silencing via translational repression...
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Peptides targeting EGFL7, a critical player in angiogenesis
Background:Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial cell...
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Schizophrenia Animal Model
Background: Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia. The social...
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Ghrelin Analogues as Molecular Imaging Probes
Background: Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues. Expression of the GHSR has been reported in various types of tumors, including breast carcinomas, prostate cancer cell lines, ovarian tumors,...
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Annexin and its Use to Treat Inflammatory Disorders
Background:Sepsis is a complex clinical syndrome resulting from a harmful host immune response to infection characterized by the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, which has been shown to be one of the main mediators of cardiovascular dysfunction. Cardiovascular dysfunction is common in patients with...
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Cell Culture Supplements for Generating Mature, Functional, Stabilized Blood Vessels In Vitro
Background: The difficulty in generating complex functional blood vessels in vitro has been an important limitation to the adoption and application of complex cell based models for functional screening and drug discovery. While the formation of endothelial tubes is well known within the academic literature, the ability to generate integrated vessels...
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