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Software System for Analyzing Three-Dimensional Image Data of a Target Region
- Application in Early Prediction of Tumour Recurrence after Stereotactic Ablative Radiotherapy for Lung Cancer
BackgroundStereotactic ablative therapy (SABR) is a standard treatment for individuals with early stage non-small lung cancer who are medically inoperable or refuse surgery. This highly conformal, high-dose radiation therapy alters the radiographic appearance of the lung during follow-up computer tomography (CT) imaging assessment in ways that are not...
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A yeast model for ALS and Distal Myopathy-2 Therapeutics
Title: A yeast model for ALS and Distal Myopathy-2 TherapeuticsSummary: A yeast model for high throughput drug and small molecule screening for ALS and Distal Myopathy-2Background: Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease caused by loss of the upper motor neurons, i.e. neurons that extend from the cortex to the...
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High Affinity RHAMM/HMMR Binding
Peptides for Imaging and Therapeutic Applications
BackgroundHyaluronan (HA) is a simple extracellular matrix polysaccharide that a wealth of experimental approaches has demonstrated actively regulates inflammation in tissue repair, fibrogenic disease processes and cancer progression. In general, large HA polymers, which are mainly present in homeostatic tissues, are immunologically quiescent and contribute...
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Novel Blood Metabolomics Profiling for Concussion Diagnosis
A metabolomics based blood test has been developed that can determine evenmild concussions with up to 95% accuracy.BackgroundTraumatic brain injury (TBI) is a major public health concern of epidemic proportions, with an annual incidence of 1.6 to 3.2 million in the United States. Mild TBI, of which concussion is a subset, is the most common representing...
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Software System for Automated Segmentation of Digitized Histological Sections for Vasculature Quantification
BackgroundImmunohistochemistry is a routine method for evaluating the distribution of antigens in microscopic tissue samples. For example, visualization of smooth muscle actin in histology is commonly used to study vascular physiology, understand disease progression and/or visualize organ development. To achieve this, the distribution of smooth muscle...
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Novel Mechanism to Control Pathogenic Potential of Staphylococcus aureus
Summary Researchers at Western University have identified a mutations in S. aureus purine biosynthesis pathway that contribute to its virulence. The current invention opens up alternate treatment and target mechanisms for hard to treat S. aureus and MRSA. Background In humans, Staphylococcus aureus may exist as a commensal bacterium or as a pathogen....
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Determining Urinary Calculi Composition
BackgroundAccurate determination of urinary stone composition has significant bearing on understanding pathophysiology, choosing treatment modalities and preventing recurrence. Several modalities to determine stone composition exist (e.g., chemical analysis, X-ray diffraction and infrared spectroscopy); however, all of these methods require direct access...
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Dual Purpose Upper and Lower Limb Rehabilitation Robot
BackgroundThere are 800,000 new cases of stroke in the United States and Canada each year. In cases of stroke, it is common for the upper and lower limbs to become weakened or paralyzed. Robotic rehabilitation systems have been developed to assist in the delivery of movement therapy to both the upper or lower extremities to maximize return of function...
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Diagnosis of Bacterial Vaginosis (BV)
BackgroundBacterial vaginosis (BV) is the most common vaginal condition, affecting an estimated 30% of women at any given time. While many women remain asymptomatic, when signs and symptoms do arise they include an elevated vaginal pH>4.5, discharge, and malodour due to amines. BV is also associated with a number of co-morbidities, including increased...
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A novel system to modulate the composition of the microbiome
TitleA novel system to modulate the composition of the microbiomeSummaryA robust state-of-the-art method to manipulate the microbiome. BackgroundMicrobial ecosystems are essential for human health and proper development, and disturbances of the ecosystem correlate with a multitude of diseases. A central problem is the lack of tools to selectively control...
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